Missouri's stretch of Route 66 delivers some of the most rewarding riding along the Mother Road, combining historic landmarks, small-town charm, and scenic Ozark landscapes. From the Gateway Arch in St. Louis to the streets of Joplin, this 317-mile journey follows a mix of preserved alignments, quiet backroads, and classic Route 66 communities. Along the way, riders will discover vintage motels, roadside attractions, colorful murals, caves, museums, and some of the best-preserved pieces of Route 66 history. With easy riding, welcoming towns, and plenty of opportunities to explore beyond the highway, Missouri offers the perfect balance of nostalgia and motorcycle adventure.